Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol.

@article{Fusser2011SpontaneousMI,
  title={Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol.},
  author={Markus Fusser and Gaute J. Nesse and Andriy Khobta and Ning Xia and Huige Li and Arne Klungland and Bernd Epe},
  journal={Carcinogenesis},
  year={2011},
  volume={32 1},
  pages={80-5}
}
Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csb(m/m)Ogg1⁻(/)⁻ mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesis in the liver if cell proliferation is stimulated. Here, we describe that the phytoalexin resveratrol, applied either for 7 days per gavage (100 mg/kg body wt) or for 3-9 months… CONTINUE READING

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