Spontaneous microdeletions and microinsertions in a transgenic mouse mutation detection system: analysis of age, tissue, and sequence specificity

@article{Halangoda2001SpontaneousMA,
  title={Spontaneous microdeletions and microinsertions in a transgenic mouse mutation detection system: analysis of age, tissue, and sequence specificity},
  author={Asanga Halangoda and Jennifer Still and Kathleen A. Hill and Steve S. Sommer},
  journal={Environmental and Molecular Mutagenesis},
  year={2001},
  volume={37}
}
A total of 3497 independent spontaneous mutations were examined using the Big Blue® transgenic mouse mutation detection system. Base substitutions predominate, although 16% of somatic and germline mutations are microdeletions, microinsertions, or deletions combined with insertions. The pattern of microdeletions and microinsertions is similar in both the lacI transgene and the human p53 gene. Single‐base deletions (D1) and insertions (I1) are evenly distributed in the lacI transgene, whereas… 
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