Spontaneous malformations of the cerebellar vermis: Prevalence, inheritance, and relationship to lobule/fissure organization in the C57BL/6 lineage.

@article{Dine2015SpontaneousMO,
  title={Spontaneous malformations of the cerebellar vermis: Prevalence, inheritance, and relationship to lobule/fissure organization in the C57BL/6 lineage.},
  author={Sarah E. Van Dine and Nga Yan Siu and Alyssa R. Toia and Joshua A. Cuoco and Adrienne J. Betz and Valerie J. Bolivar and German Torres and Raddy L. Ramos},
  journal={Neuroscience},
  year={2015},
  volume={310},
  pages={242-51}
}
The complex neuronal circuitry of the cerebellum is embedded within its lamina, folia, and lobules, which together play an important role in sensory and motor function. Studies in mouse models have demonstrated that both cerebellar lamination and lobule/fissure development are under genetic control. The cerebellar vermis of C57BL/6 mice exhibits spontaneous malformations of neuronal migration of posterior lobules (VIII-IX; molecular layer heterotopia); however, the extent to which other inbred… CONTINUE READING
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