Spontaneous loss of heterozygosity in diploid Saccharomyces cerevisiae cells.

@article{Hiraoka2000SpontaneousLO,
  title={Spontaneous loss of heterozygosity in diploid Saccharomyces cerevisiae cells.},
  author={Mina Hiraoka and Kimitsuna Watanabe and Keiko Umezu and Hisaji Maki},
  journal={Genetics},
  year={2000},
  volume={156 4},
  pages={1531-48}
}
To obtain a broad perspective of the events leading to spontaneous loss of heterozygosity (LOH), we have characterized the genetic alterations that functionally inactivated the URA3 marker hemizygously or heterozygously situated either on chromosome III or chromosome V in diploid Saccharomyces cerevisiae cells. Analysis of chromosome structure in a large number of LOH clones by pulsed-field gel electrophoresis and PCR showed that chromosome loss, allelic recombination, and chromosome aberration… CONTINUE READING

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