Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice.

@article{Bzard2000SpontaneousLC,
  title={Spontaneous long-term compensatory dopaminergic sprouting in MPTP-treated mice.},
  author={Erwan B{\'e}zard and Sandra Dovero and Christine Imbert and Thomas Boraud and Christian Eric Gross},
  journal={Synapse},
  year={2000},
  volume={38 3},
  pages={363-8}
}
The present study sought to determine whether severe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication elicits spontaneous long-term compensatory sprouting in mice. Animals, once treated, were kept without further treatment for 0.5, 1, 5, or 7 months. The stability of the nigral degeneration was checked by evaluation of the number of tyrosine hydroxylase immunoreactive (TH-IR) neurons, whereas sprouting was assessed using both [(3)H]-dopamine (DA) uptake by striatal synaptosomes… CONTINUE READING