Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.

@article{Scharfman2002SpontaneousLS,
  title={Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor.},
  author={Helen E Scharfman and Jeffrey H. Goodman and Anne L. Sollas and Susan D. Croll},
  journal={Experimental neurology},
  year={2002},
  volume={174 2},
  pages={201-14}
}
The results of several studies have contributed to the hypothesis that BDNF promotes seizure activity, particularly in adult hippocampus. To test this hypothesis, BDNF, vehicle (phosphate-buffered saline, PBS), or albumin was infused directly into the hippocampus for 2 weeks using osmotic minipumps. Rats were examined behaviorally, electrophysiologically… CONTINUE READING