Spontaneous lesions in beagle dogs used in toxicity studies.

@article{Morishima1990SpontaneousLI,
  title={Spontaneous lesions in beagle dogs used in toxicity studies.},
  author={Hajime Morishima and Takashi Nonoyama and Shigekazu Sasaki and Hirofumi Miyajima},
  journal={Jikken dobutsu. Experimental animals},
  year={1990},
  volume={39 2},
  pages={239-48}
}
Spontaneous histopathologic lesions were examined in 276 young beagle dogs (8 to 15 months old) used in toxicity studies. Mononuclear cell infiltration in the liver was observed with the highest incidence (more than 95%). Calcium deposition in the kidney, mononuclear cell infiltration in the salivary glands, pigmentation in the spleen, and cortical atrophy in the thymus were seen with relatively high incidences (more than 30%). The incidence of mononuclear cell infiltration in the gallbladder… CONTINUE READING
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