Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.

@article{Hassaguerre1998SpontaneousIO,
  title={Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins.},
  author={Michel Ha{\"i}ssaguerre and Pierre Ja{\"i}s and Dipen C Shah and Atsushi Takahashi and M{\'e}l{\`e}ze Hocini and Gilles Quiniou and St{\'e}phane Garrigue and A Le Mouroux and Philippe Le M{\'e}tayer and Jacques Cl{\'e}menty},
  journal={The New England journal of medicine},
  year={1998},
  volume={339 10},
  pages={
          659-66
        }
}
BACKGROUND Atrial fibrillation, the most common sustained cardiac arrhythmia and a major cause of stroke, results from simultaneous reentrant wavelets. Its spontaneous initiation has not been studied. METHODS We studied 45 patients with frequent episodes of atrial fibrillation (mean [+/-SD] duration, 344+/-326 minutes per 24 hours) refractory to drug therapy. The spontaneous initiation of atrial fibrillation was mapped with the use of multielectrode catheters designed to record the earliest… Expand
Atrial Fibrillation: Role of Arrhythmogenic Foci
TLDR
Pulmonary veins play an important role in paroxysmal atrial fibrillation, they are the most frequent source of focal atrialfibrillation and of initiating foci amenable to RF ablation. Expand
Modes of initiation of paroxysmal atrial fibrillation from analysis of spontaneously occurring episodes using a 12-lead Holter monitoring system.
TLDR
Paroxysmal AF is triggered most frequently by monomorphic left APCs, and in most AF episodes, the increase in the number of ectopic beats that initiated episodes of AF occurred at a normal sinus rate. Expand
Role of Rapid Focal Activation in the Maintenance of Atrial Fibrillation Originating from the Pulmonary Veins
TLDR
Widespread conduction of RFA from a PV at its source to the other sites may be necessary for the sustenance of AF. Expand
The role of atrial ectopics in initiating paroxysmal atrial fibrillation.
TLDR
Paroxysmal atrial fibrillation is preceded by ectopics of a fixed coupling interval in a significant proportion of patients, and Holter techniques may provide a useful screening tool with which to identify patients suitable for fuller electrophysiological assessment. Expand
Prevention of paroxysmal atrial fibrillation by permanent septal atrial pacing: long-term follow up
TLDR
The rate of progression to permanent atrial fibrillation in patients paced at the inter-atrial septum was evaluated, and sinus rhythm was maintained in 79·8% of the group overall after 50 months. Expand
A Simple Method of Mapping Atrial Premature Depolarizations Triggering Atrial Fibrillation
TLDR
The activation sequence and relative timing of the recordings obtained with the catheter configuration was highly predictive of right and left atrial origin and, more importantly, ofright and left PV foci. Expand
High-rate pacing-induced atrial fibrillation effectively reveals properties of spontaneously occurring paroxysmal atrial fibrillation in humans.
  • D. Calvo, F. Atienza, +8 authors O. Berenfeld
  • Medicine
  • Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
  • 2012
TLDR
In patients with paroxysmal AF, high-rate pacing-induced AF adequately mimics spontaneously initiated AF, regardless of induction site, according to off-line power spectral analysis of bipolar electrograms. Expand
Catheter Ablation of Atrial Fibrillation Originating from
TLDR
A decapolar catheter was positioned in the superior vena cava to map the origin of the atrial fibrillation in a 39-year-old female patient who had a 3-year history of symptomatic atrial tachycardia and fibrilation and there was no recurrence of atrial arrhythmia after a 14-month follow-up. Expand
Biatrial multisite mapping of atrial premature complexes triggering onset of atrial fibrillation.
TLDR
It was shown that 47% of ectopic foci triggering the onset of AF were located outside the pulmonary veins in extravenous parts of the left atrium and the right atrium, and 27% of patients had AF onsets of bifocal origin, challenging the current opinion that extrapulmonary foci play a minor role in inducing AF. Expand
Ablation of Atrial Fibrillation
TLDR
Based on experimental studies and clinical studies that used a variety of catheter and surgical ablation techniques, it is possible to postulate two major mechanisms for the initiation and perpetuation of atrial fibrillation: primary drivers and multiple wavelet reentry. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
SPONTANEOUS INITIATION OF ATRIAL FIBRILLATION BY ECTOPIC BEATS ORIGINATING IN THE PULMONARY VEINS SPONTANEOUS INITIATION OF ATRIAL FIBRILLATION BY ECTOPIC BEATS ORIGINATING IN THE PULMONARY VEINS
A BSTRACT Background Atrial fibrillation, the most common sustained cardiac arrhythmia and a major cause of stroke, results from simultaneous reentrant wavelets. Its spontaneous initiation has notExpand
A focal source of atrial fibrillation treated by discrete radiofrequency ablation.
TLDR
In some patients, the surface ECG pattern of atrial fibrillation is due to a focal rapidly firing source of activity that can be eliminated by discrete radiofrequency energy applications. Expand
Radiofrequency catheter modification of atrioventricular conduction to control the ventricular rate during atrial fibrillation.
TLDR
A catheter technique to modify atrioventricular conduction without creating pathologic atriventricular block is feasible in the majority of patients with symptomatic atrial fibrillation and a rapid ventricular rate refractory to drug therapy. Expand
The surgical treatment of atrial fibrillation. II. Intraoperative electrophysiologic mapping and description of the electrophysiologic basis of atrial flutter and atrial fibrillation.
TLDR
The presence of macroreentrant circuits and the absence of either microreentrants or evidence of atrial automaticity suggests that atrial fibrillation should be amenable to surgical ablation. Expand
Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats.
TLDR
Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF. Expand
Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation.
TLDR
This model was consistently associated with biatrial myopathy and marked changes in atrial vulnerability, and was readily inducible in most dogs (82%) after rapid atrial pacing. Expand
High-density mapping of electrically induced atrial fibrillation in humans.
TLDR
During pacing-induced AF in humans, the RA is activated by one or multiple wavelets propagating in different directions, which appears to be characterized by different numbers and dimensions of the intra-atrial reentrant circuits. Expand
Radiofrequency catheter ablation of the atria reduces inducibility and duration of atrial fibrillation in dogs.
BACKGROUND The purpose of this study was to prevent induction of sustained atrial fibrillation (AF) by radiofrequency catheter ablation (RFCA) of the atria in an open-chest canine model. METHODSExpand
The Role of Premature Beats in the Initiation and the Termination of Supraventricular Tachycardia in the Wolff‐Parkinson‐White Syndrome
TLDR
In four patients with WPW syndrome atrial and ventricular premature beats were induced and the changes in form of the ventricular and atrial complexes were studied, results suggest that a circus movement involving the atria, the normal atrioventricular conduction system and the Kent bundle is present. Expand
Surgical therapy of paroxysmal atrial fibrillation with the "corridor" operation.
TLDR
The results demonstrate that the concept of the corridor operation is sound and justify its use in the treatment of drug-refractory paroxysmal atrial fibrillation. Expand
...
1
2
3
4
...