Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis


N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in meiotic recombinant N1F1 mice that caused an abnormal pain sensitivity phenotype with spontaneous skin inflammation in the paws and ears. We… (More)
DOI: 10.1186/1423-0127-19-55


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