Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

@article{Probert1995SpontaneousID,
  title={Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.},
  author={Lesley Probert and Katerina Akassoglou and Manolis Pasparakis and George Kontogeorgos and George Kollias},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 24},
  pages={11294-8}
}
Cytokines are now recognized to play important roles in the physiology of the central nervous system (CNS) during health and disease. Tumor necrosis factor alpha (TNF-alpha) has been implicated in the pathogenesis of several human CNS disorders including multiple sclerosis, AIDS dementia, and cerebral malaria. We have generated transgenic mice that constitutively express a murine TNF-alpha transgene, under the control of its own promoter, specifically in their CNS and that spontaneously develop… CONTINUE READING

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