Spontaneous hibernomas in Sprague-Dawley rats.

  title={Spontaneous hibernomas in Sprague-Dawley rats.},
  author={Richard H. Bruner and Meliton N. Novilla and Catherine A Picut and Jeannie B Kirkpatrick and Thomas P O'Neill and Kathryn L Scully and Wade B Lawrence and Dawn G. Goodman and Brett H Saladino and David G. Peters and George A. Parker},
  journal={Toxicologic pathology},
  volume={37 4},
Hibernomas are rare neoplasms originating in brown adipose tissue of humans and other animal species, including laboratory animals. Background incidence values for these tumors in all common strains of laboratory rats are generally accepted as being <0.1%. Between April 2000 and April 2007, however, sixty-two hibernomas (an overall prevalence of 3.52%) were observed in a total of 1760 Sprague-Dawley rats assigned to three carcinogenesis bioassays at two separate research laboratories. All rats… CONTINUE READING