Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis.

@article{Brustein2013SpontaneousGC,
  title={Spontaneous glycine-induced calcium transients in spinal cord progenitors promote neurogenesis.},
  author={Edna Brustein and S{\'e}bastien C{\^o}t{\'e} and Julien Ghislain and Pierre Drapeau},
  journal={Developmental neurobiology},
  year={2013},
  volume={73 2},
  pages={168-75}
}
Glycine and GABA are depolarizing during early development, but the purpose of this paradoxical chloride-mediated depolarization remains unclear, especially at early stages. It was previously reported that suppressing glycine signaling from the beginning of development in zebrafish embryos caused an abnormal maintenance of the progenitor population and a specific reduction of spinal interneurons but not of other cell populations. Here, we show that cells including progenitors in the embryonic… CONTINUE READING

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Here , we show that cells including progenitors in the embryonic spinal cord had occasional spontaneous , glycine - mediated calcium transients that were blocked by the glycine antagonist strychnine and the L - type calcium channel blocker nifedipine .
Here , we show that cells including progenitors in the embryonic spinal cord had occasional spontaneous , glycine - mediated calcium transients that were blocked by the glycine antagonist strychnine and the L - type calcium channel blocker nifedipine .
Glycine and GABA are depolarizing during early development , but the purpose of this paradoxical chloride - mediated depolarization remains unclear , especially at early stages .
Glycine and GABA are depolarizing during early development , but the purpose of this paradoxical chloride - mediated depolarization remains unclear , especially at early stages .
Here , we show that cells including progenitors in the embryonic spinal cord had occasional spontaneous , glycine - mediated calcium transients that were blocked by the glycine antagonist strychnine and the L - type calcium channel blocker nifedipine .
Here , we show that cells including progenitors in the embryonic spinal cord had occasional spontaneous , glycine - mediated calcium transients that were blocked by the glycine antagonist strychnine and the L - type calcium channel blocker nifedipine .
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