Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function.

@article{Ridley2008SpontaneousFO,
  title={Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function.},
  author={J M Ridley and Heping Cheng and Oliver J Harrison and Steven K. Jones and Godfrey L. Smith and Jules C. Hancox and Clive H Orchard},
  journal={Cell calcium},
  year={2008},
  volume={44 6},
  pages={580-91}
}
Spontaneous Ca(2+) release from the sarcoplasmic reticulum (SR) appears to play an important role in cardiac sinoatrial node pacemaking. However, comparatively little is known about the role of intracellular Ca(2+) in the atrioventricular node (AVN). Intracellular Ca(2+) was therefore monitored in cells isolated from the rabbit AVN, using fluo-3 in conjunction with confocal microscopy. These cells displayed spontaneous Ca(2+) transients and action potentials. Ca(2+) transients were normally… CONTINUE READING

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