Spontaneous formation of conjugates of alpha-methyl-DOPA and DOPA with serum proteins and experimental production of specific antibodies against these haptens.

@article{Cirstea1983SpontaneousFO,
  title={Spontaneous formation of conjugates of alpha-methyl-DOPA and DOPA with serum proteins and experimental production of specific antibodies against these haptens.},
  author={M. C. Cirstea and G S Suhaciu and M C{\^i}rje},
  journal={Physiologie},
  year={1983},
  volume={20 1},
  pages={3-10}
}
Alpha-methyldopa (alpha MD) and levodopa (DOPA) react readily with serum proteins at alkaline pH and form stable conjugates with them. Hapten specific antibodies in high titers are produced in rabbits by inoculation of the conjugates formed by alpha MD and DOPA with normal rabbit serum (alpha MD-NRS and DOPA-NRS), incorporated in incomplete Fruend adjuvant. No hapten specific antibodies were raised in rabbits inoculated with alpha MD as such, incorporated in adjuvant, with alpha MD mixed with… CONTINUE READING