Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum

  title={Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum},
  author={Joshua A. Goldberg and John N. J. Reynolds},
Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?
This mini-review article compares pause types, as well as current key hypotheses for inputs underlying pauses that include dopamine-induced inhibition through D2-receptors, a GABA input from ventral tegmental area, and a prolonged afterhyperpolarization induced by excitatory input from the cortex or from the thalamus.
Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents
It is demonstrated that synaptically released dopamine inhibits CINs through type 2 dopamine receptors, while another unidentified transmitter mediates the delayed excitation, which implies that, in addition to their direct effects on striatal projection neurons, midbrain dopamine neurons indirectly modulate striatal output by dynamically controlling cholinergic tone.
Potentiation of NMDA receptor-mediated transmission in striatal cholinergic interneurons
It is found that high frequency stimulation of commissural corticostriatal afferents from the contralateral hemisphere induced a robust long-term depression (LTD) of postsynaptic potentials (PSP) in CINs.
Firing Pattern Characteristics of Tonically Active Neurons in Rat Striatum: Context Dependent or Species Divergent?
It is demonstrated that TAN activity is substantially influenced by event context; yet, under identical task conditions, primate and rat TANs display similar activity patterns, whereas under different conditions they do not.
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum
It is reported that long-term potentiation at corticostriatal synapses with SPNs is dependent on the coincidence of pauses in ChIs and phasic dopamine activation, critically accompanied by SPN depolarisation, which constrains the synapses eligible for plasticity.
Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
It is shown that midbrain cholinergic nuclei provide a new source of Ach in the striatum, form excitatory synapses with striatal Cholinergic interneurons (CIN) and contribute to instrumental learning.
Relationships between the Firing of Identified Striatal Interneurons and Spontaneous and Driven Cortical Activities In Vivo
These striatal interneuron types have distinct temporal signatures in vivo, including relationships to spontaneous and driven cortical activities, which likely underpin their specialized contributions to striatal microcircuit function.
Coordinated Postnatal Maturation of Striatal Cholinergic Interneurons and Dopamine Release Dynamics in Mice
It is revealed that postnatal maturation of ChI activity is due primarily to enhanced INaP and an interaction between developing cholinergic signaling and DA neurotransmission in the juvenile striatum is identified, revealing a change in the frequency-dependence of DA release during the early postnatal period that is mediated by cholinerential signaling.


Modulation of an Afterhyperpolarization by the Substantia Nigra Induces Pauses in the Tonic Firing of Striatal Cholinergic Interneurons
It is found that both subthreshold and suprathreshold depolarizations in cholinergic interneurons induced a prolonged after-hyperpolarization (AHP) associated with a pause in their tonic firing, which may underlie the acquisition of the pause response in TANs recorded from behaving animals during learning.
Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events
  • P. Apicella
  • Biology, Psychology
    The European journal of neuroscience
  • 2002
Data suggest that the TANs respond as do detectors of motivationally relevant events, but they also demonstrate that these neurons are influenced by predictive information based on past experience with a given temporal context, suggesting a unique subset of striatal neurons that might serve a modulatory function, monitoring for temporal relationships between environmental events.
Visual-Induced Excitation Leads to Firing Pauses in Striatal Cholinergic Interneurons
Tonically active neurons in the primate striatum, believed to be cholinergic interneurons (CINs), respond to sensory stimuli with a pronounced pause in firing. Although inhibitory and neuromodulatory
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning
It is concluded that, during the acquisition of a sensorimotor association, TANs widely distributed through the striatum become responsive to sensory stimuli that induce conditioned behavior.
Tonically active neurons in the striatum differentiate between delivery and omission of expected reward in a probabilistic task context
It is found that only a subset of TANs could detect the extent to which reward occurs differently than predicted, thus contributing to the encoding of positive and negative reward prediction errors that is relevant to reinforcement learning.