Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum

@article{Goldberg2011SpontaneousFA,
  title={Spontaneous firing and evoked pauses in the tonically active cholinergic interneurons of the striatum},
  author={Joshua A. Goldberg and John N. J. Reynolds},
  journal={Neuroscience},
  year={2011},
  volume={198},
  pages={27-43}
}
The tonically active neurons (TANs) are a population of neurons scattered sparsely throughout the striatum that show intriguing patterns of firing activity during reinforcement learning. Following repeated pairings of a neutral stimulus with a primary reward, TANs develop a transient cessation of firing activity in response to the stimulus, termed the "conditioned pause response." In tasks where specific cues are arranged to signal the probability of particular outcomes, the pause response to… Expand
Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?
TLDR
This mini-review article compares pause types, as well as current key hypotheses for inputs underlying pauses that include dopamine-induced inhibition through D2-receptors, a GABA input from ventral tegmental area, and a prolonged afterhyperpolarization induced by excitatory input from the cortex or from the thalamus. Expand
Multiphasic Modulation of Cholinergic Interneurons by Nigrostriatal Afferents
TLDR
It is demonstrated that synaptically released dopamine inhibits CINs through type 2 dopamine receptors, while another unidentified transmitter mediates the delayed excitation, which implies that, in addition to their direct effects on striatal projection neurons, midbrain dopamine neurons indirectly modulate striatal output by dynamically controlling cholinergic tone. Expand
Potentiation of NMDA receptor-mediated transmission in striatal cholinergic interneurons
TLDR
It is found that high frequency stimulation of commissural corticostriatal afferents from the contralateral hemisphere induced a robust long-term depression (LTD) of postsynaptic potentials (PSP) in CINs. Expand
Firing Pattern Characteristics of Tonically Active Neurons in Rat Striatum: Context Dependent or Species Divergent?
TLDR
It is demonstrated that TAN activity is substantially influenced by event context; yet, under identical task conditions, primate and rat TANs display similar activity patterns, whereas under different conditions they do not. Expand
Coordinated postnatal maturation of striatal cholinergic interneurons and dopamine release dynamics in mice
TLDR
It is demonstrated that ChI spontaneous activity increases with age while the duration of the pause in firing induced by depolarizing inputs decreases during postnatal development, and a developmental link between ChI activity and dopamine release is reported, revealing a change in the frequency-dependence of dopamine release during the early postnatal period that is mediated by cholinergic signaling. Expand
Cholinergic midbrain afferents modulate striatal circuits and shape encoding of action strategies
TLDR
It is shown that midbrain cholinergic nuclei provide a new source of Ach in the striatum, form excitatory synapses with striatal Cholinergic interneurons (CIN) and contribute to instrumental learning. Expand
The Cholinergic Interneuron of the Striatum
TLDR
Recent findings that underscore the fast nicotinic action of cholinergic interneurons on striatal circuitry, especially when these neurons are activated synchronously are reviewed. Expand
Pause and rebound: sensory control of cholinergic signaling in the striatum
TLDR
Evidence of mechanisms that have been proposed to underlie sensory responses, including antagonistic actions by dopamine, recurrent inhibition via local interneurons, and an intrinsically generated membrane hyperpolarization in response to excitatory inputs are discussed. Expand
Relationships between the Firing of Identified Striatal Interneurons and Spontaneous and Driven Cortical Activities In Vivo
TLDR
These striatal interneuron types have distinct temporal signatures in vivo, including relationships to spontaneous and driven cortical activities, which likely underpin their specialized contributions to striatal microcircuit function. Expand
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
TLDR
It is shown that polysynaptic inhibition between ChINs is a robust network motif and instrumental in shaping the network activity of ChIN's, and the involvement of striatal tyrosine hydroxylase-expressing interneurons in mediating this inhibition is shown. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 130 REFERENCES
Modulation of an Afterhyperpolarization by the Substantia Nigra Induces Pauses in the Tonic Firing of Striatal Cholinergic Interneurons
TLDR
It is found that both subthreshold and suprathreshold depolarizations in cholinergic interneurons induced a prolonged after-hyperpolarization (AHP) associated with a pause in their tonic firing, which may underlie the acquisition of the pause response in TANs recorded from behaving animals during learning. Expand
Visual-Induced Excitation Leads to Firing Pauses in Striatal Cholinergic Interneurons
Tonically active neurons in the primate striatum, believed to be cholinergic interneurons (CINs), respond to sensory stimuli with a pronounced pause in firing. Although inhibitory and neuromodulatoryExpand
Tonically active neurons in the primate striatum and their role in the processing of information about motivationally relevant events
  • P. Apicella
  • Psychology, Medicine
  • The European journal of neuroscience
  • 2002
TLDR
Data suggest that the TANs respond as do detectors of motivationally relevant events, but they also demonstrate that these neurons are influenced by predictive information based on past experience with a given temporal context, suggesting a unique subset of striatal neurons that might serve a modulatory function, monitoring for temporal relationships between environmental events. Expand
Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning
TLDR
It is concluded that, during the acquisition of a sensorimotor association, TANs widely distributed through the striatum become responsive to sensory stimuli that induce conditioned behavior. Expand
The corticostriatal input to giant aspiny interneurons in the rat: a candidate pathway for synchronising the response to reward-related cues
TLDR
Giant aspiny interneurons are under the significant influence of spontaneous excitatory inputs and receive specialised input from either faster conducting or less branching cortical fibres than spiny projection neurons. Expand
The Mechanism of Intrinsic Amplification of Hyperpolarizations and Spontaneous Bursting in Striatal Cholinergic Interneurons
TLDR
The duration and even the sizes of spontaneous and driven hyperpolarizations and pauses in spontaneous activity in cholinergic interneurons are largely autonomous properties of the neuron, rather than reflections of characteristics of the input eliciting the response. Expand
Thalamic Gating of Corticostriatal Signaling by Cholinergic Interneurons
TLDR
It was found that activation of thalamostriatal axons in a way that mimicked the response to salient stimuli induced a burst of spikes in striatal cholinergic interneurons that was followed by a pause lasting more than half a second. Expand
Tonically active neurons in the striatum differentiate between delivery and omission of expected reward in a probabilistic task context
TLDR
It is found that only a subset of TANs could detect the extent to which reward occurs differently than predicted, thus contributing to the encoding of positive and negative reward prediction errors that is relevant to reinforcement learning. Expand
The Cholinergic Interneurons of the Striatum: Intrinsic Properties Underlie Multiple Discharge Patterns
TLDR
The extended and dense axonal arborization of the network of cholinergic interneurons, combined with their shared pause responses in primates, led to the proposal that these neurons act in concert to modulate activity of the whole striatal network. Expand
Coincident but Distinct Messages of Midbrain Dopamine and Striatal Tonically Active Neurons
TLDR
It is concluded that the striatal cholinergic and dopaminergic systems carry distinct messages by different means, which can be integrated differently to shape the basal ganglia responses to reward-related events. Expand
...
1
2
3
4
5
...