Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice.

Abstract

Aging is the single most common risk factor for cancer. Peripheral and marrow-derived stem cells are long lived and are candidate cells for the cancer-initiating cell. Repeated rounds of replication are likely required for accumulation of the necessary genetic mutations. Based on the facts that mesenchymal stem cells (MSC) transform with higher frequency… (More)

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Cite this paper

@article{Li2007SpontaneousEO, title={Spontaneous expression of embryonic factors and p53 point mutations in aged mesenchymal stem cells: a model of age-related tumorigenesis in mice.}, author={Hanchen Li and Xueli Fan and Ramesh C. Kovi and Yunju Jo and Brian Moquin and Richard F Konz and Calin Stoicov and Evelyn A Kurt-Jones and Steven R. Grossman and Steven Lyle and Arlin B. Rogers and Marshall H. Montrose and Jeanmarie Houghton}, journal={Cancer research}, year={2007}, volume={67 22}, pages={10889-98} }