Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridine.

  title={Spontaneous epileptiform discharges in hippocampal slices induced by 4-aminopyridine.},
  author={Rob A. Voskuyl and Henk Albus},
  journal={Brain research},
  volume={342 1},
4-Aminopyridine (4-AP) induced 2 types of spontaneous field potentials (SFPs) in the hippocampal slice. Type I resembled spontaneous activity induced by other convulsants. They occurred at a rate of approximately 1 Hz, started in the CA2/CA3 region and spread at a velocity of 0.3 m/s to area CA1. Transsection experiments and laminar profiles indicated that they spread synaptically along the Schaffer collateral pathway. Synaptic blockade by low Ca2+/high Mg2+ or kynurenic acid reversibly… CONTINUE READING
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