Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury.

@article{Yang2010SpontaneousEA,
  title={Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury.},
  author={Lie Yang and Sonia Afroz and H. Michelson and J. Goodman and H. Valsamis and D. S. Ling},
  journal={Journal of neurotrauma},
  year={2010},
  volume={27 8},
  pages={
          1541-8
        }
}
A hallmark of severe traumatic brain injury (TBI) is the development of post-traumatic epilepsy (PTE). However, the mechanisms underlying PTE remain poorly understood. In this study, we used a controlled cortical impact (CCI) model in rats to examine post-traumatic changes in neocortical excitability. Neocortical slices were prepared from rats at 7-9 days (week 1) and 14-16 days (week 2) after CCI injury. By week 2, we observed a substantial gray matter lesion with a cavity that extended to the… Expand
Cortical Excitation and Inhibition following Focal Traumatic Brain Injury
Neural circuit mechanisms of post–traumatic epilepsy
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 41 REFERENCES
Epileptogenesis in chronically injured cortex: in vitro studies.
Chronic neocortical epileptogenesis in vitro.
Epileptogenesis following neocortical trauma from two sources of disinhibition.
...
1
2
3
4
5
...