Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring.

  title={Spontaneous domain formation in disordered copolymers as a mechanism for chromosome structuring.},
  author={Matteo Negri and Marco Gherardi and Guido Tiana and Marco Cosentino Lagomarsino},
  journal={Soft matter},
  volume={14 29},
Motivated by the problem of domain formation in chromosomes, we studied a co-polymer model where only a subset of the monomers feel attractive interactions. These monomers are displaced randomly from a regularly-spaced pattern, thus introducing some quenched disorder in the system. Previous work has shown that in the case of regularly-spaced interacting monomers this chain can fold into structures characterized by multiple distinct domains of consecutive segments. In each domain, attractive… 


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