Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding.

@article{Faure2003SpontaneousCA,
  title={Spontaneous clustering and tyrosine phosphorylation of NK cell inhibitory receptor induced by ligand binding.},
  author={Mathias Faure and Domingo F Barber and Stephenie M. Takahashi and Tian Jin and Eric O Long},
  journal={Journal of immunology},
  year={2003},
  volume={170 12},
  pages={
          6107-14
        }
}
Inhibition of NK cell cytotoxicity by killer cell Ig-like receptors (KIR) depends on phosphorylation of cytoplasmic tyrosines in KIR, which recruit tyrosine phosphatase Src homology protein tyrosine phosphatase 1. It is not clear how KIR, whose function lies downstream of a tyrosine kinase, succeeds in blocking proximal NK cell activation signals upon binding HLA class I on target cells. Here we show that mixing NK cells with insect cells expressing HLA-C was sufficient to induce clustering of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

Similar Papers

Loading similar papers…