Spontaneous changes in the rate of decline in reciprocal serum creatinine: errors in predicting the progression of renal disease from extrapolation of the slope.

@article{Shah1992SpontaneousCI,
  title={Spontaneous changes in the rate of decline in reciprocal serum creatinine: errors in predicting the progression of renal disease from extrapolation of the slope.},
  author={Babubhai V. Shah and Andrew S. Levey},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1992},
  volume={2 7},
  pages={1186-91}
}
The slope of reciprocal serum creatinine (1/Pcr) versus time has been used to measure the rate of progression of chronic renal disease, predict the interval until onset of end-stage renal disease, and assess the effect of therapy. In order to determine the errors that might result from extrapolating the slope of 1/Pcr versus time beyond the interval of observation, we applied a method of linear regression analysis to search for spontaneous changes in slope in 21 patients from New England… CONTINUE READING

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