Spontaneous cell fusion and PCC formation in Bloom's syndrome

Abstract

Corresponding to 4,633 diploid lymphocytes 64 tetraploid or near-tetraploid (including one octoploid) metaphases were found in two sibs with Bloom's syndrome. Eight of the polyploid cells had resulted from cell fusion with half the chromosomes representing PCC. One similar fibroblast was also observed. In 13, 584 untreated cells from persons without a… (More)
DOI: 10.1007/BF00344601

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