Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition.

@article{Ono2007SpontaneousAF,
  title={Spontaneous atrial fibrillation initiated by triggered activity near the pulmonary veins in aged rats subjected to glycolytic inhibition.},
  author={Norihiko Ono and Hideki Hayashi and Ayaka Kawase and Shien-Fong Lin and Hongmei Li and James N. Weiss and Peng-Sheng Chen and Hrayr S. Karagueuzian},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={292 1},
  pages={H639-48}
}
Aging and glycolytic inhibition (GI) are known to alter intracellular calcium ion (Ca(i)(2+)) handling in cardiac myocytes, causing early afterpotentials (EADs) and delayed afterpotentials. We hypothesized that aging and GI interact synergistically in intact hearts to generate EADs and triggered activity leading to atrial fibrillation (AF). We studied isolated and Langendorff-perfused hearts of young (age 3-5 mo, N = 8) and old (age 27-29 mo, N = 14) rats subjected to GI (0 glucose + 10 mmol/l… CONTINUE READING