Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation

@article{Parri2001SpontaneousAC,
  title={Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation},
  author={H. Rheinallt Parri and Timothy M. Gould and Vincenzo Crunelli},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={803-812}
}
Astrocytes respond to chemical, electrical and mechanical stimuli with transient increases in intracellular calcium concentration ([Ca2+]i). We now show that astrocytes in situ display intrinsic [Ca2+]i oscillations that are not driven by neuronal activity. These spontaneous astrocytic oscillations can propagate as waves to neighboring astrocytes and trigger slowly decaying NMDA receptor-mediated inward currents in neurons located along the wave path. These findings show that astrocytes in situ… CONTINUE READING
BETA

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 256 CITATIONS

Astrocytic GABA transporter GAT-1 dysfunction in experimental absence seizures.

VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Homer1 Scaffold Proteins Govern Ca2+ Dynamics in Normal and Reactive Astrocytes.

  • Cerebral cortex
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Glutamatergic input–output properties of thalamic astrocytes

VIEW 8 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Sustained neuronal activity generated by glial plasticity.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2011
VIEW 14 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

A mathematical model of spontaneous calcium(II) oscillations in astrocytes.

  • Journal of theoretical biology
  • 2008
VIEW 13 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2019

CITATION STATISTICS

  • 35 Highly Influenced Citations

  • Averaged 11 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 54 REFERENCES

Intercellular calcium signaling and gap junctional articles nature neuroscience

C. Giaume, L. Venance
  • Glia 24,
  • 2001

Imaging extracellular waves of glutamate during calcium signaling in cultured astrocytes.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000

SNARE protein-dependent glutamate release from astrocytes.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2000

ATP released from astrocytes mediates glial calcium waves.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1999

Similar Papers

Loading similar papers…