Spontaneous apoptosis in human colon tumor cell lines and the relation of wt p53 to apoptosis.


OBJECTIVE To examine spontaneous apoptosis of cultured human colon tumor cell lines in vitro and to investigate the role of wild type (wt) p53 in regulation of apoptosis induced by DNA-damaging treatment. METHODS A model system of human tumor progression involving three cell lines was used in this study for examination of apoptosis. They were originally… (More)


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