Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2.

  title={Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55212-2.},
  author={Mario D. G. Aceto and Susan M Scates and Benson B. Martin},
  journal={European journal of pharmacology},
  volume={416 1-2},
Physical dependence on the synthetic cannabinoid-receptor agonist R(+)-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate (WIN 55212-2) was demonstrated in rats by the use of a chronic continuous infusion. Spontaneous withdrawal, of moderate intensity, was shown for the first time with this class of drugs of abuse. Behavioral withdrawal signs were also elicited after challenge with (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4… CONTINUE READING


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