Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry.

@article{Lalonde2007SpontaneousAI,
  title={Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry.},
  author={Robert Lalonde and Catherine Strazielle},
  journal={Brain research},
  year={2007},
  volume={1140},
  pages={51-74}
}
Grid2(Lc) (Lurcher), Grid2(ho) (hot-foot), Rora(sg) (staggerer), nr (nervous), Agtpbp1(pcd) (Purkinje cell degeneration), Reln(rl) (reeler), and Girk2(Wv) (Weaver) are spontaneous mutations with cerebellar atrophy, ataxia, and deficits in motor coordination tasks requiring balance and equilibrium. In addition to these signs, the Dst(dt) (dystonia musculorum) spinocerebellar mutant displays dystonic postures and crawling. More recently, transgenic models with human spinocerebellar ataxia… CONTINUE READING