Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients.

@article{Trippi2001SpontaneousAI,
  title={Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients.},
  author={F. Trippi and Nicoletta Botto and Roberto Scarpato and Lucia Petrozzi and Ubaldo Bonuccelli and Stefania Latorraca and Sandro Sorbi and Lucia Migliore},
  journal={Mutagenesis},
  year={2001},
  volume={16 4},
  pages={323-7}
}
Alzheimer's disease (AD) is a neurodegenerative disorder of the elderly with a complex etiology due to the interaction between genetic and environmental factors. At least 15% of cases are inherited as an autosomal dominant mutation, but the majority are sporadic. We evaluated cytogenetic alterations, both spontaneous and chemical-induced [aluminium (Al) and griseofulvin (GF)], by means of the micronucleus (MN) test in lymphocytes or skin fibroblasts of 14 patients with sporadic and eight with… CONTINUE READING

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