Spontaneous and artificial lesions of magnocellular reticular formation of brainstem deteriorate avoidance learning in senescence-accelerated mouse SAM.

@article{Yagi1998SpontaneousAA,
  title={Spontaneous and artificial lesions of magnocellular reticular formation of brainstem deteriorate avoidance learning in senescence-accelerated mouse SAM.},
  author={Hiromi Yagi and Ichiro Akiguchi and Akira Ohta and Nobuya Yagi and Masanori Hosokawa and Tadahiro Takeda},
  journal={Brain research},
  year={1998},
  volume={791 1-2},
  pages={90-8}
}
The role of the magnocellular reticular formation (MGRF) of the brainstem on learning and memory was examined in memory-deficient mice with spontaneous spongy degeneration in the brainstem (senescence-accelerated mouse, SAMP8) and control mice (accelerated-senescence resistant mouse, SAMR 1). SAMP8 showed spontaneous age-related impairment of learning and memory, as determined by passive and active avoidance responses. The deficits of learning and memory function in passive avoidance… CONTINUE READING