Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

@article{Hacker2006SpontaneousAU,
  title={Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.},
  author={Elke Hacker and Hans Konrad Muller and Nicole G Irwin and Brian G Gabrielli and Dino Lincoln and Sandra Jane Pavey and Marianne Broome Powell and Marcos Malumbres and Mariano Barbacid and N. K. Hayward and Graeme J. Walker},
  journal={Cancer research},
  year={2006},
  volume={66 6},
  pages={2946-52}
}
Human melanoma susceptibility is often characterized by germ-line inactivating CDKN2A (INK4A/ARF) mutations, or mutations that activate CDK4 by preventing its binding to and inhibition by INK4A. We have previously shown that a single neonatal UV radiation (UVR) dose delivered to mice that carry melanocyte-specific activation of Hras (TPras) increases melanoma penetrance from 0% to 57%. Here, we report that activated Cdk4 cooperates with activated Hras to enhance susceptibility to melanoma in… CONTINUE READING

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