Spontaneous and IL-2-induced anti-leukemic and anti-host effects against tumor- and host-specific alloantigens.

@article{Cohen1993SpontaneousAI,
  title={Spontaneous and IL-2-induced anti-leukemic and anti-host effects against tumor- and host-specific alloantigens.},
  author={Philip S. Cohen and U Vourka-Karussis and Lola Weiss and Shimon Slavin},
  journal={Journal of immunology},
  year={1993},
  volume={151 9},
  pages={4803-10}
}
The graft-vs-leukemia (GVL) effect and its connection to graft-vs-host disease (GVHD) were studied in F1 hybrid mice after parental bone marrow transplantation. (BALB/c x C57BL/6) F1 mice (F1) were sublethally and lethally irradiated and inoculated with 10(4) BCL1 cells, a murine leukemia of BALB/c (BALB) origin. Subsequently mice were transplanted with F1 (syngeneic), BALB (allogeneic to the host but syngeneic to the tumor), C57BL/6 (B6) (allogeneic to both host and tumor) spleen cells, or… CONTINUE READING