Spontaneous and Engineered Compensatory HSV Mutants that Counteract the Host Antiviral PKR Response

Abstract

A virulent recombinant HSV lacking the diploid γ(1)34.5 gene (Δγ(1)34.5) have been investigated over the last two decades both for anti-tumor therapy and as vaccine vectors. The first generation vectors, while safe, are incapable of sustained replication in the majority of treated patients. An interferon inducible host antiviral kinase, protein kinase R… (More)
DOI: 10.3390/v1030510

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