Spontaneous alternation, motor activity, and spatial learning in hot-foot mutant mice

@article{Filali1996SpontaneousAM,
  title={Spontaneous alternation, motor activity, and spatial learning in hot-foot mutant mice},
  author={M. Maskani Filali and Robert Lalonde and A. N. Bensoula and J. -M. Guastavino and F. Lestienne},
  journal={Journal of Comparative Physiology A},
  year={1996},
  volume={178},
  pages={101-104}
}
Hot-foot mutant mice, characterized by defective innervation of Purkinje cells and an ataxic gait, were less active than normal mice in a T-maze. In spontaneous alternation testing with either single or multiple trials, hot-foot mutants, contrary to normal mice, did not alternate above chance. Moreover, the mutants had a higher number of errors and higher escape latencies in a water-filled Z-maze. These results indicate that in addition to motor coordination deficits, these cerebellar mutants… CONTINUE READING

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