Spontaneous activity of guinea pig ileum longitudinal muscle regulated by Ca(2+)-activated K+ channel.

@article{Hong1997SpontaneousAO,
  title={Spontaneous activity of guinea pig ileum longitudinal muscle regulated by Ca(2+)-activated K+ channel.},
  author={S. J. Hong and Y F Roan and C. Chiung Chang},
  journal={The American journal of physiology},
  year={1997},
  volume={272 5 Pt 1},
  pages={G962-71}
}
Isolated guinea pig ileum displayed spontaneous contraction and fluctuation of membrane potential originating from the longitudinal muscle. Transmural stimulation of the enteric nerve plexus evoked contractions that were followed by lowered muscle tone and decreased spontaneous activity. The Na+ channel blocker tetrodotoxin, N-type Ca2+ channel blockers omega-conotoxins GVIA and MVIIA, the muscarinic receptor antagonist atropine, and inhibitory mediators alpha, beta-methylene-ATP and sodium… CONTINUE READING

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