Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

@article{Bischoff1990SpontaneousAI,
  title={Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.},
  author={Farideh Z. Bischoff and Sun O Yim and Sen Pathak and Geraldine Grant and Michael J. Siciliano and Beppino C. Giovanella and Louise C. Strong and Michael A. Tainsky},
  journal={Cancer research},
  year={1990},
  volume={50 24},
  pages={7979-84}
}
Families of patients with the Li-Fraumeni cancer syndrome have an inherited pattern of sarcomas and various other types of cancers that follow a dominant mode of transmission, an early age of onset, and exhibit multiple primary tumors. As soft tissue sarcomas (including fibrosarcomas) are frequently observed with this syndrome, the in vitro growth characteristics of fibroblasts derived from skin biopsies of Li-Fraumeni syndrome patients were studied. Control fibroblasts maintained a normal… CONTINUE READING

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