Spontaneous Proliferation in Organotypic Cultures of Mouse Cochleae

  title={Spontaneous Proliferation in Organotypic Cultures of Mouse Cochleae},
  author={Ding Da–lian and Wang Ji-an and Yu Zhi-ping and Jiang Hai–yan and Wang Ping and Richard J. Salvi},
Abstract Cells in mammalian cochleae virtually stop proliferation and exit cellular circle before birth. Consequently, hair cells and spiral ganglion neurons destroyed by ototoxic factors cannot be replaced through proliferative regeneration. However, substantial proliferation occurs in organotypic cultures of cochleae from postnatal mice. In the present study, we studied the time course of proliferative growth in cultures of mouse cochlea explants obtained from up to 12 postnatal days. The… CONTINUE READING