Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice: Evidence of Dissociation as a Function of Age at Weaning

@article{Adriani2002SpontaneousNS,
  title={Spontaneous Novelty Seeking and Amphetamine-induced Conditioning and Sensitization in Adult Mice: Evidence of Dissociation as a Function of Age at Weaning},
  author={Walter Adriani and Giovanni Laviola},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={27},
  pages={225-236}
}
Individual differences in coping with novelty and in the response to psychoactive drugs have been related to early life events, such as the age of weaning. Outbred CD-1 mice underwent a precocious (postnatal day (pnd) 15, Wean-15 group), regular (pnd 21, Wean-21 group), or delayed (pnd 27, Wean-27 group) weaning, and were tested as adults (pnd > 60). In Experiment 1, animals underwent a treatment history with d-amphetamine (AMPH 0, 1, or 5 mg/kg once/day for three days) in a familiar… CONTINUE READING