Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis

@inproceedings{Pkalski2013SpontaneousNA,
  title={Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis},
  author={J Pȩkalski and Pawel J. Zuk and Marek Kochańczyk and Michael Junkin and Ryan Kellogg and Savaş Tay and Tomasz Lipniacki},
  booktitle={PloS one},
  year={2013}
}
NF-κB is a key transcription factor that regulates innate immune response. Its activity is tightly controlled by numerous feedback loops, including two negative loops mediated by NF-κB inducible inhibitors, IκBα and A20, which assure oscillatory responses, and by positive feedback loops arising due to the paracrine and autocrine regulation via TNFα, IL-1 and other cytokines. We study the NF-κB system of interlinked negative and positive feedback loops, combining bifurcation analysis of the… CONTINUE READING

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