Spontaneous Locomotor Activity and Dopamine Levels in Tyr-1 Mutants of Drosophila Melanogaster

@inproceedings{Burnell1982SpontaneousLA,
  title={Spontaneous Locomotor Activity and Dopamine Levels in Tyr-1 Mutants of Drosophila Melanogaster},
  author={Ann M. Burnell and Bernadette A. Daly},
  year={1982}
}
The pathways involved in tyrosine metabolism in insects are complex. Tyrosine serves as the precursor for melanin, sclerotin and the neuroactive catecholamines, dopamine and noradrenalin (see Fig. 1). Early workers (Ohnishi, 1954; Horowitz and Fling, 1955) demonstrated that fresh tissue extracts of Drosophila contained no measurable tyrosinase activity but following a time lag (during which the extract is maintained at O°C) tyrosinase activity develops. Horowitz and Fling (1955) noted that the… CONTINUE READING