Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.

@article{Wang2016SpontaneousHC,
  title={Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.},
  author={Qi Wang and Wan-Ni Yu and Xinyu Chen and Xiao-Ding Peng and Sang Min Jeon and Morris J Birnbaum and Grace Guzman and Nissim Hay},
  journal={Cancer cell},
  year={2016},
  volume={29 4},
  pages={523-535}
}
Akt is frequently hyperactivated in human cancers and is targeted for cancer therapy. However, the physiological consequences of systemic Akt isoform inhibition were not fully explored. We showed that while combined Akt1 and Akt3 deletion in adult mice is tolerated, combined Akt1 and Akt2 deletion induced rapid mortality. Akt2(-/-) mice survived hepatic Akt1 deletion but all developed spontaneous hepatocellular carcinoma (HCC), which is associated with FoxO-dependent liver injury and… CONTINUE READING
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Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms

  • Wang
  • Cancer Cell (2016),
  • 2016
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