• DOI:10.1359/JBMR.050406
Corpus ID: 28699531

Spontaneous Fractures in the Mouse Mutant sfx Are Caused by Deletion of the Gulonolactone Oxidase Gene, Causing Vitamin C Deficiency

@article{Mohan2005SpontaneousFI,
  title={Spontaneous Fractures in the Mouse Mutant sfx Are Caused by Deletion of the Gulonolactone Oxidase Gene, Causing Vitamin C Deficiency},
  author={Subburaman Mohan and A. Kapoor and Anny Singgih and Z. Zhang and Tim F. Taylor and H. Yu and R. Chadwick and Yoon-Sok Chung and L. R. Donahue and C. Rosen and G. C. Crawford and J. Wergedal and D. Baylink},
  journal={Journal of Bone and Mineral Research},
  year={2005},
  volume={20}
}

Subburaman Mohan, A. Kapoor, +10 authors D. Baylink

Published 2005

Biology, Medicine

Journal of Bone and Mineral Research

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Using a mouse mutant that fractures spontaneously and dies at a very young age, we identified that a deletion of the GULO gene, which is involved in the synthesis of vitamin C, is the cause of impaired osteoblast differentiation, reduced bone formation, and development of spontaneous fractures.