Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice

@article{Bygrave2004SpontaneousAI,
  title={Spontaneous Autoimmunity in 129 and C57BL/6 Mice—Implications for Autoimmunity Described in Gene-Targeted Mice},
  author={Anne E. Bygrave and Kirsten L. Rose and Josefina Cortes-Hernandez and Joanna Warren and Robert J. Rigby and H Terence Cook and Mark J. Walport and Timothy J Vyse and Marina Botto},
  journal={PLoS Biology},
  year={2004},
  volume={2},
  pages={355 - 360}
}
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder in which complex genetic factors play an important role. Several strains of gene-targeted mice have been reported to develop SLE, implicating the null genes in the causation of disease. However, hybrid strains between 129 and C57BL/6 mice, widely used in the generation of gene-targeted mice, develop spontaneous autoimmunity. Furthermore, the genetic background markedly influences the autoimmune phenotype of SLE in gene… CONTINUE READING