Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.

@article{Kim2007SpongiformNE,
  title={Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.},
  author={Bong Yoon Kim and James A. Olzmann and Gregory S Barsh and Lih-Shen Chin and Lian Li},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 4},
  pages={
          1129-42
        }
}
A null mutation in the gene encoding the putative E3 ubiquitin-protein ligase Mahogunin causes spongiform neurodegeneration, a recessively transmitted prion-like disease in mice. However, no substrates of Mahogunin have been identified, and the cellular role of Mahogunin is unknown. Here, we report the identification of TSG101, a key component of the endosomal sorting complex required for transport (ESCRT)-I, as a specific Mahogunin substrate. We find that Mahogunin interacts with the ubiquitin… CONTINUE READING
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