Spongiadioxins A and B, two new polybrominated dibenzo-p-dioxins from an Australian marine sponge Dysidea dendyi.

@article{Utkina2001SpongiadioxinsAA,
  title={Spongiadioxins A and B, two new polybrominated dibenzo-p-dioxins from an Australian marine sponge Dysidea dendyi.},
  author={Natalia K Utkina and Vladimir Denisenko and Olga V. Scholokova and Marina V. Virovaya and Andrey V. Gerasimenko and D. Yu. Popov and Vladimir B. Krasokhin and Alexander M. Popov},
  journal={Journal of natural products},
  year={2001},
  volume={64 2},
  pages={
          151-3
        }
}
Two new cytotoxic tetrabromodibenzo-p-dioxins, spongiadioxins A (1) and B (2), were isolated from an Australian marine sponge Dysidea dendyi. The structures of these compounds were established by 1D and 2D NMR spectroscopy, X-ray analysis of the methyl ether of spongiadioxin A (3), and synthesis of the methyl ether of spongiadioxin B (4) from diphenyl ether (9) isolated from Dysidea herbacea. 
New polychlorinated pyrrolidinones from the Red Sea marine sponge Lamellodysidea herbacea
Abstract Chemical investigation of the dichloromethane extract of the Red Sea marine sponge Lamellodysidea herbacea led to the isolation of seven new polychlorinated derivatives 3–6 and 8–10 in
Dysideanones A-C, unusual sesquiterpene quinones from the South China Sea sponge Dysidea avara.
TLDR
Dysideanones A-C (1-3), three unusual sesquiterpene quinones with unprecedented carbon skeletons, were isolated from the South China Sea sponge Dysidea avara and showed cytotoxicity against two human cancer cell lines.
Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase.
Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor
Enzymatic Synthesis of Polybrominated Dioxins from the Marine Environment
TLDR
It is reported that the bmp gene locus in marine bacteria, a recently characterized source of polybrominated diphenyl ethers, can also synthesize dibenzo-p-dioxins by employing different phenolic initiator molecules.
Sponge-derived polybrominated diphenyl ethers and dibenzo-p-dioxins, irreversible inhibitors of the bacterial α-d-galactosidase.
TLDR
It was revealed for the first time that all compounds rapidly and apparently irreversibly inhibited the bacterial α-d-galactosidase and all compounds bind in a pocket close to the catalytic amino acid residues.
Marine sponge: a potential source for methoxylated polybrominated diphenyl ethers in the Asia-Pacific food web.
TLDR
It is indicated that marine sponges are a possible source of the MeO-PBDE analogues that biomagnify via the food chain to the higher trophic organisms in the western Pacific, whereas the distribution of the corresponding hydroxylated analogues is limited.
Typification of Chemical Compoundsof Marine Sponge Metabolites
Sponges are the storehouse of extraneous marine biota paving way for the formation of unique structured organic compounds with interesting biological activities either by themselves or by their
40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)—A Historical Overview and Newest Data of a Promising Anticancer Drug
TLDR
It is shown that P01F08 induces apoptosis mainly through the intrinsic mitochondrial pathway, and this article provides novel data of a promising anticancer therapeutic PBDE (i.e., 4,5,6-tribromo-2-(2′,4′-dibromophenoxy)phenol; termed P 01F08).
The diversity of naturally produced organohalogens.
More than 3800 organohalogen compounds, mainly containing chlorine or bromine but a few with iodine and fluorine, are produced by living organisms or are formed during natural abiogenic processes,
Contemporary 14C radiocarbon levels of oxygenated polybrominated diphenyl ethers (O-PBDEs) isolated in sponge-cyanobacteria associations.
TLDR
The modern radiocarbon content of diphenyl ethers, C(12)H(22)O) indicates that they are naturally produced, adding to a growing baseline on, at least, the sources of these unusual compounds.
...
1
2
3
4
5
...