Sponge Paleogenomics Reveals an Ancient Role for Carbonic Anhydrase in Skeletogenesis

  title={Sponge Paleogenomics Reveals an Ancient Role for Carbonic Anhydrase in Skeletogenesis},
  author={Daniel J. Jackson and Luciana Macis and Joachim Reitner and Bernard M. Degnan and Gert W{\"o}rheide},
  pages={1893 - 1895}
Sponges (phylum Porifera) were prolific reef-building organisms during the Paleozoic and Mesozoic ∼542 to 65 million years ago. These ancient animals inherited components of the first multicellular skeletogenic toolkit from the last common ancestor of the Metazoa. Using a paleogenomics approach, including gene- and protein-expression techniques and phylogenetic reconstruction, we show that a molecular component of this toolkit was the precursor to the α-carbonic anhydrases (α-CAs), a gene… 

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