Spondin-2, a secreted extracellular matrix protein, is a novel diagnostic biomarker for prostate cancer.

@article{Lucarelli2013Spondin2AS,
  title={Spondin-2, a secreted extracellular matrix protein, is a novel diagnostic biomarker for prostate cancer.},
  author={Giuseppe Lucarelli and Monica Rutigliano and Carlo Bettocchi and Silvano Palazzo and Antonio Vavallo and Vanessa Galleggiante and Senia Maria Rosaria Trabucco and Daniela Di Clemente and Francesco Paolo Selvaggi and Michele Battaglia and Pasquale Ditonno},
  journal={The Journal of urology},
  year={2013},
  volume={190 6},
  pages={2271-7}
}
PURPOSE SPON2 belongs to the F-spondin family of secreted extracellular matrix proteins. It is deregulated in some tumors, including prostate cancer. In this prospective study we assessed the role of serum SPON2 as a biomarker for prostate cancer diagnosis as well as any association between SPON2 levels and clinicopathological features. We also compared the diagnostic performance of this biomarker to that of serum sarcosine, and percent free-to-total and total prostate specific antigen… CONTINUE READING
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