Spo0A, the key transcriptional regulator for entrance into sporulation, is an inhibitor of DNA replication.

@article{CastillaLlorente2006Spo0ATK,
  title={Spo0A, the key transcriptional regulator for entrance into sporulation, is an inhibitor of DNA replication.},
  author={Virginia Castilla-Llorente and Daniel Mu{\~n}oz-Esp{\'i}n and Laurentino Villar and M. Salas and Wilfried J J Meijer},
  journal={The EMBO journal},
  year={2006},
  volume={25 16},
  pages={
          3890-9
        }
}
The transcription factor Spo0A is a master regulator for entry into sporulation in Bacillus subtilis and also regulates expression of the virulent B. subtilis phage phi29. Here, we describe a novel function for Spo0A, being an inhibitor of DNA replication of both, the phi29 genome and the B. subtilis chromosome. Binding of Spo0A near the phi29 DNA ends, constituting the two origins of replication of the linear phi29 genome, prevents formation of phi29 protein p6-nucleoprotein initiation complex… CONTINUE READING
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