Splitting the chromosome: cutting the ties that bind sister chromatids.

@article{Nasmyth2000SplittingTC,
  title={Splitting the chromosome: cutting the ties that bind sister chromatids.},
  author={Kim Nasmyth and Jeffrey M. Peters and Frank Uhlmann},
  journal={Science},
  year={2000},
  volume={288 5470},
  pages={
          1379-85
        }
}
In eukaryotic cells, sister DNA molecules remain physically connected from their production at S phase until their separation during anaphase. This cohesion is essential for the separation of sister chromatids to opposite poles of the cell at mitosis. It also permits chromosome segregation to take place long after duplication has been completed. Recent work has identified a multisubunit complex called cohesin that is essential for connecting sisters. Proteolytic cleavage of one of cohesin's… CONTINUE READING
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