Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G.

@article{Zavialov2005SplittingOT,
  title={Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G.},
  author={Andrey V. Zavialov and Vasili Hauryliuk and M{\aa}ns Ehrenberg},
  journal={Molecular cell},
  year={2005},
  volume={18 6},
  pages={675-86}
}
After peptide release by a class-1 release factor, the ribosomal subunits must be recycled back to initiation. We have demonstrated that the distance between a strong Shine-Dalgarno (SD) sequence and a codon in the P site is crucial for the binding stability of the deacylated tRNA in the P site of the posttermination ribosome and the in-frame maintenance of its mRNA. We show that the elongation factor EF-G and the ribosomal recycling factor RRF split the ribosome into subunits in the absence of… CONTINUE READING

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