SplitCore: An exceptionally versatile viral nanoparticle for native whole protein display regardless of 3D structure

@inproceedings{Walker2011SplitCoreAE,
  title={SplitCore: An exceptionally versatile viral nanoparticle for native whole protein display regardless of 3D structure},
  author={Andreas Walker and Claudia Skamel and Michael Nassal},
  booktitle={Scientific reports},
  year={2011}
}
Nanoparticles displaying native proteins are attractive for many applications, including vaccinology. Virus-based nanoparticles are easily tailored by genetic means, commonly by inserting heterologous sequences into surface-exposed loops. The strategy works well with short peptides but is incompatible with the structures of most native proteins, except those with closely juxtaposed termini. Here we overcome this constraint by splitting the capsid protein of hepatitis B virus, one of the most… CONTINUE READING
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